Blood Pressure Correlates Asymmetrically with Neuropeptidase Activities of the Left and Right Frontal Cortices

It was suggested that the brain-heart connection is asymmetrically organized. However, evidence connecting neurochemical factors from each brain hemisphere with changes in cardio-vascular functions have not yet been reported. In order to analyze potential asymmetrical connections between functions, we studied level of correlations left and right frontal cortex (FC) soluble (Sol) membrane-bound (MB) neuropeptide-degrading enzymes alanyl (AlaAP), cystinyl (CysAP), glutamyl (GluAP) aminopeptidase activities, involved among others metabolism angiotensins, heart rate (HR), systolic (SBP), diastolic (DBP) blood pressure, rats treated or hypotensive hypertensive drugs such as captopril, propranolol L-NAME. The present study suggests existence a bidirectional these neuropeptidases functions. Specifically, depending on treatment, control group, Sol AlaAP FC correlates negatively SBP DBP. captopril-treated animals, MB CysAP GluAP correlate HR. L-NAME rats, No significant were observed group. Considering together all values obtained four groups regardless drug results demonstrated negative neuropeptidase mainly cortex, levels pressure. Remarkably, findings contrast drastically previously reported indicating positive other peripheral water intake diuresis. Both represent noteworthy information strongly supports concept asymmetric organization neurovisceral integration involving processes physiological most probably mediated by autonomic nervous system. Overall, suggest cognitive may be connected processes, vice versa.